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The characteristics often spread in one mouse habitat to another, suggesting a spreading microbial an infection is responsible. However the traits also regularly pass from mom to offspring, suggesting a genetic trigger. Thaddeus Stappenbeck, MD, PhD, a professor of immunology and pathology, and co-senior writer Virgin, the Edward Mallinckrodt Professor of mind and Pathology of the Division of Pathology and Immunology, encountered this problem within their research of inflammatory bowel illnesses, such as for example Crohn's disease and ulcerative colitis. These were amazed to find that approximately half their mice acquired low amounts in the gut of IgA, an antibody associated with these disorders.