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The main strength of the anti-CCP antibodies appear in people who may be negative for rheumatoid factor, where an anti – CCP test may be useful for both the diagnosis and prognosis. Discussion in the GDG report also noted that an anti – CCP test useful for people who test positive for rheumatoid factor, but is not where the clinical sense of RA. A positive anti – CCP test in these circumstances would suggest in-vitro at an increased risk for RA then, and should followed closely. But as it is currently only limited data in this group of patients , the GDG concluded that a formal recommendation would be premature. Doris – Ann Williams, Director General of BIVDA, the UK trade association for companies provides in-vitro diagnostic products, said: ‘NICE is now considering evaluation process for medical technologies, including diagnostics, detection of potentially important role in IVD played in health care I think NICE. Recommendations always carry significant weight in the medical practice ‘.

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