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Chromatin regulation not governed by a uniform histone code In a novel usage of gene knockout technology, experts at the University of California, NORTH PARK School of Medicine tested the same gene inserted into 90 different locations in a yeast chromosome – and discovered that while the inserted gene under no circumstances altered its encircling chromatin landscape, differences for the reason that immediate scenery measurably affected gene activity. The findings, published on-line in the Jan. 3 problem of Cell Reviews, demonstrate that regulation of chromatin – the mix of DNA and proteins that comprise a cell's nucleus – is not governed by a uniform histone code but by specific interactions between chromatin and genetic factors.