CB1 receptors are located on cells in the mind called neurons. So if cannabis substances put on these CB1 receptors, they can disrupt the normal regulation of conversation in the brain. Could you please give a brief launch to the endocannabinoid program? The physical body makes its cannabis-like chemicals, called endocannabinoids. These endocannabinoids become messengers between your cells of your body. In the brain, endocannabinoids put on CB1 receptors located on neurons to modify the true method that the neurons communicate with each other.But also for some, Chiari malformations could cause headaches, balance problems, and other symptoms. What Is a Chiari Malformation? Chiari malformation is a condition that causes the cerebellum — the area of the brain that settings coordination and muscle movement — to push in to the space occupied by the spinal cord normally. Most kids who have it are born with the problem, but some develop it because they grow. Normally, the cerebellum sits behind the skull, above the spine just. When a child has a Chiari malformation, the area for the cerebellum is sometimes too little or unusually shaped. This can squeeze area of the cerebellum and even portion of the human brain stem down through a funnel-like hole below the skull.