Cilag, POZEN enter license agreement to build up and commercialize MT 400 POZEN Inc natural way . , a pharmaceutical company focused on transforming medication that transforms lives, today announced that it offers entered into a license agreement with Cilag GmbH International, a division of Johnson & Johnson, for the advancement and commercialization of MT 400 in Brazil, Colombia, Peru and Ecuador. MT 400 is normally POZEN’s proprietary combination of sumatriptan and naproxen sodium, the first multiple system triptan therapy for the treating migraine. POZEN licensed U previously.S. Related StoriesCalcitonin-gene related peptide antibody inhibition displays migraine avoidance promiseCombatting viral and bacterial lung infections with volatile anesthetics: an interview with Dr ChakravarthyMigraines may boost risk of stroke among smokersUnder the conditions of the agreement, Cilag will end up being POZEN’s distinctive licensee for MT 400 in the licensed territory and will be responsible for the manufacturing, commercialization and development of MT 400. Cilag will make an initial upfront payment to POZEN, followed by a milestone payment to POZEN upon the approval of MT 400 by the National Health Surveillance Company of Brazil. The agreement will expire on a country-by-country basis upon the 15th anniversary of the initial commercial sale of MT 400 in each country. Through the first 10 years of sales, Cilag shall pay POZEN a high single digit royalty on net sales of MT 400, followed by a low single digit royalty through the next 5 years. ‘We are pleased to have reached an agreement with Cilag to build up and commercialize MT 400 in several countries in Latin America,’ said Liz Cermak, Executive Vice President and Chief Commercial Officer of POZEN. ‘This is a first step in bringing this novel migraine product to the an incredible number of migraine sufferers living beyond the United States. Furthermore, the income from this deal can help fuel the development and commercialization of our integrated aspirin ‘PA’ portfolio of products.’ MT 400 has been proven to be superior to triptan monotherapy on multiple efficacy endpoints. In a published Phase 2 clinical trial involving 972 patients previously, POZEN announced that MT 400, using a marketed triptan and an NSAID, provided a larger than 50 % improvement for sustained treatment over triptan monotherapy with an identical side effect profile. Sustained pain relief is defined as patients achieving treatment within two hours of dosing and neither relapsing nor using rescue medicine over the next 22 hours.
Cigarette smokers treated for human brain aneurysm with coil embolization in higher risk of recurrence Cigarette smokers who were treated for cerebral aneurysms with coil embolization are in greater threat of developing another aneurysm, claim neurological surgeons in Jefferson Hospital for Neuroscience in Philadelphia in the first-known research of its kind. In the April problem of the Journal of Neurosurgery In a paper published, researchers found there is an increased threat of recanalization , specifically in low-grade aneurysmal subarrachnoid hemorrhage patients with a brief history of using tobacco, says Erol Veznedaroglu, M.D., associate professor of Neurological Surgery and director of the Division of Neurovascular Surgery and Endovascular Neurosurgery at Jefferson Medical University of Thomas Jefferson University and Thomas Jefferson University Hospital. Annually, aneurysmal subarachnoid hemorrhages are located in one case per 10 approximately,000. The study’s authors executed a retrospective chart review of all instances involving patients admitted to their institution in 2003 for treatment of a cerebral aneurysm by coil embolization or coiling. In coiling, a catheter is usually inserted into an artery in the groin, advanced in to the affected artery in the mind then. The surgeon then locations one or more tiny coils through the catheter in to the aneurysm. The physical body responds by forming a blood clot around the coil, blocking off the aneurysm. Related StoriesPublic health plans targeting smokers could possibly have opposite effect, study findsLiposomal sizing and the Coulter basic principle: an interview with Professor Melvin E. KlegermanKARL STORZ equips brand-new Nuffield Wellness Cambridge HospitalThe authors sought out any correlation among the location and size of the treated aneurysm, the incidence of coil compaction, and days gone by history of smoking as elements for recurrence. But there is no significant indication that aneurysm size and location, type of coil and packing density had been causing the higher risk. Veznedaroglu. The number of cigarettes smoked was also found to have an impact on the increased threat of developing an aneurysm, he adds. Veznedaroglu says.