Difficulty with at least one activity of everyday living was cited by 9.4 million noninstitutionalized adults. These activities included getting around inside the true home, bathing, eating and dressing. Of these social people, 5 million required the help of others to perform this activity. About 15.5 million adults had difficulties with one or more instrumental activities of everyday living. These activities included performing housework, using the phone and preparing foods.Simon Pedder, Chelsea’s President and CEO. We are very happy to have such experienced and distinguished thought leaders signing up for us in this forum to share new insight into the motor and non-motor dysfunction in Parkinson’s disease, the critical function of norepinephrine in the pathophysiology of the condition and the therapeutic potential of our norepinephrine pro-drug, Northera. Parkinson’s disease is the second most common neurodegenerative disorder in America. As a total result of decreased degrees of norepinephrine associated with PD, up to around 20 percent of these patients may experience NOH symptoms linked to the disease or as a complication of medicine. NOH is normally a neurogenic disorder caused by deficient launch of norepinephrine, the neurotransmitter used by sympathetic autonomic nerves to send out signals to the blood vessels and the heart to regulate blood circulation pressure.